Link to contestant photos -- https://www.misssouthcarolinausa.com/contestants-miss/
- Two 2016 RPM Teens, both top 3 at Miss Teen USA 2016, going head to head - Emily Wakeman Miss NC Teen USA 2016, 1RU at Miss Teen USA and Marley Stokes Miss SC Teen USA 2016, 2RU at Miss Teen USA and 3RU at Miss SC USA last year.
- 3/5 of last year's top five and 2/5 of the 2019 top five are back
- Caitlin Russell is returning after missing 2020; Riley Copans is competing for the first time since 2018 (she won Miss Collegiate America 2019) & in SC for the first time.
- Also a former Miss SC (Davia Bunch/4RU last year) & SC Outstanding Teen (Hope Harvard) in the mix.
- In Teen, two of last year's top five are back (Ava Nicole Randall & Kendall Rivers)